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Lifting the invisible ceiling on gene therapy
Genetic medicines have transformed from theoretical to transformative, but they face a fundamental biological constraint. As therapeutic DNA becomes larger, more synthetic, and more complex, cells increasingly recognise it as intrusive and silence its activity over time. This cellular gene-silencing response limits therapeutic potency, shortens durability, and prevents the treatment of some diseases entirely. For developers, it's an invisible ceiling: an unmapped biological limit that caps patient outcomes, constrains treatment efficacy, and drives up manufacturing costs and dosing requirements across the industry.
Houdini Bio has discovered a new layer in therapeutic DNA design. Using ARCANA, their AI-powered platform, they decode and engineer escape routes around the cellular gene-silencing machinery, enabling sustained therapeutic expression whilst preserving biological function. In validated models, this translates to substantially higher expression, improved durability, lower dose requirements, and significantly better cost effectiveness. The result is computationally designed, biologically proven and modality-agnostic, compounding with existing therapies without changes to supply chains or manufacturing processes.

Outcompeting gas boilers with green heat
$10.7BN is currently spent annually on fossil fuel-powered industrial gas boilers for low and mid-grade heat. ~$150BN is spent annually on fuel. The obvious alternative is heat pumps, but despite their higher efficiency, existing designs have similar or higher opex to gas boilers because of the cost of electricity. This is in addition to the fact that available heat pumps can cost 4x the capex of gas boilers. But volatile gas prices and pressure to reduce emissions make this an unstable equilibrium.
HotGreen's design combines 2x TRL 9 technologies in a novel array to achieve efficiencies that are up to double the efficiency of existing solutions whilst also driving down capex, allowing total decarbonisation, reduced energy costs and greater cost-base predictability: all with a payback of less than 2 years.

Software eats engineering design
Engineering design is one of the most expensive, slow moving processes in the development of new technology, dependent on top down direction from senior engineering leads and implementation and iteration by a large cohort of junior engineers. Despite work often being similar across tasks and industries, each must be done manually in the precise engineering context.
Flow automates the majority of manual execution work within an engineering company: 30x cheaper, 12x faster and with an 8x smaller team. They’re backed by Sequoia, as well as by senior figures at NASA, ESA and BAE Systems.

Fully automated cell manufacturing platform
A significant component of biotech is manual preparation and growth of cells. This is expanding exponentially as therapeutics themselves become cell-based, most notably in cancer treatment. This is not just a significant time sink, it often involves significant waste, scope for human error and limits reproducibility.
Mytos have developed a system to fully automate cell manufacturing. Each machine completes the work of 10 scientists, whilst also reducing wastage and improving consistency.